Estrogen Defense

The human body produces its own estrogen, part of this process is called Aromatization. After the age of 50 years old, this process is more accelerated and becomes even more prominent, setting up potential major problems for woman with familial history of breast cancer, uterine and ovarian cancer. For man , Aromatization exacerbates prostate hypertrophy and increase risk of cancer due to increased levels of estrogen. Did you know that a man at the age of 55 has as much or even more estrogen than a woman of 55 years old??? Yes, this is a fact. In the article published by Osborne CK, et al, “Estrogen self proliferation and implication for treatment of breast cancer” Cancer Treatment Research 1988, reported that the increase of estrogen level for women lead to a potential increase in cancer particularly in cervical, ovarian, breast and endometrium. Extensive research confirmed recent studies that Brassica vegetables have strong active ingredient in the form of Indol-3-Carbinol (I3C). I3C shows promise in cancer prevention as well as an estrogen hormone modulator, reported by Vonpoppel GFO, et al, “Brassica vegetables and cancer prevention”. Adv Exp Med Bio 1999. Terry P, et al. “Brassica vegetables and breast cancer risk” Jama 2001.

When I3C is ingested in the stomach, and mixed with the stomach acid, another very active and more powerful ingredient Diindolylmethane (DIM) is produced, which is a vital natural compound known to have potent anti cancer and anti tumor properties. Both I3C and the converted DIM has proven to lower the circulating estrogen, estradial (E2) by quickly neutralizing and excreted by the liver. Benabadji SH et al., Anti estrogenic and antioxidant diindolylmethane. Octa pharmacol sin 2004.

In order to get sufficient amount of I3C and DIM, a person has to eat very large quantities of vegetables such as broccoli or 103 pieces of Brussels sprouts, ¼ head of raw cabbage in order for it to do any good, many people find these dietary requirements impossible to meet on a daily basis, therefore, the National Cancer Institute and the National Cancer Prevention Center have shown interest in the natural cancer prevention agents for breast, cervical, endometrial, colorectal cancers as well as prostate cancers, I3C and DIM, Balk JL et al., Indol-3-Carbinol for cancer prevention. Alt. Med. Rev. 2000 and Wong GY et al Indol-3-Carbinol for breast cancer prevention J. cell biochem 1997.

In males, the aging problem of hypertrophic of prostate and prostate cancer becomes more severe as we advance in age when the level of estrogen rises from the aromatization of testosterone into estrogen produced by our body. It is believed by many researchers that both I3C as well as DIM has an important part to play in mitigating the effects of estrogen on prostate cancer and prostate hypertrophy. These compounds are used in prevention as well as treatment. Nachshonketmi M et al. I3C and DIM induced apoptosis in human prostate cancer cells.Food Chem Toxic 2003.

Beyond cancer, I3C and DIM also play an important beneficial part on all immune diseases and other abnormalities. McAlidon DE et al. I3C effect in women with SLE (Systemic Lupus) on estrogen metabolism.Lupus 2001. Other additional powerful anti-estrogen ingredients contained in this proprietary formula are Fermented Grape Skin and Seed containing an extraordinary active ingredient called Resveratrol as well as the natural Chrysin an extract from vegetables and a long respected Asian extract Evodia. These ingredients work synergistically on anti-estrogen through different pathways and mechanism in a balanced formulation that is not available anywhere else in the world.

Directions:  Take one capsule twice daily or more as needed. Adjust dosages per your special condition, or as instructed by your health care practitioner.

Packaging:  60 capsules per bottle.

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